Genomics

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Cumulative low doses of the organic pesticide rotenone in the adult rat substantia nigra pars compacta


ABSTRACT: Adult male Sprague Dawley rats (5 month-old at the beginning of the study) were subcutaneously exposed to 0.5 mg.kg/d rotenone or the corresponding solvent (PEG/DMSO, 1/1) for 28 days. At the end of the experiment, animals were sacrificed by decapitation and brains were rapidly taken out within 30-40 s. Total RNA was prepared from laser-capture microdissected rat substantia nigra pars compacta (Snpc). Changes in transcript abundance within SNpc were analyzed on samples from solvent and rotenone-exposed groups (n = 3 per group) using CodeLink™ Rat Whole Genome bioarrays containing 34,000 transcripts and EST probes (GE Healthcare, Amersham, Saclay, France).

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE22364 | GEO | 2015/12/31

SECONDARY ACCESSION(S): PRJNA127675

REPOSITORIES: GEO

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