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Gene expression profile at single cell level of CD45+ tumor-infiltrating immune cells in lung adenocarcinoma patients

ABSTRACT: Fibrocytes are bone marrow-derived cells expressing fibroblast markers. We used single cell RNA sequencing (scRNA-seq) to analyze the tumor-infiltrating fibrocytes in the lung adenocarcinoma patients

ORGANISM(S): Homo sapiens

PROVIDER: GSE223923 | GEO | 2023/11/29

REPOSITORIES: GEO

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Gene expression profile at single cell level of CD45+ tumor-infiltrating immune cells in msothelioma-bearing mice

Project description:Fibrocytes are bone marrow-derived cells expressing fibroblast markers. We used single cell RNA sequencing (scRNA-seq) to analyze the tumor-infiltrating fibrocytes in the lung adenocarcinoma patients

2023-03-30 | GSE223998 | GEO

Tumor Infiltrating Lymphocytes and Immune-Related Genes as Predictors of Outcome in Pancreatic Adenocarcinoma

Project description:Background. We investigated the correlation of pancreatic ductal adenocarcinoma patient prognosis with the presence of tumor infiltrating lymphocytes and expression of 521 immune system genes. Methods. Intratumoral CD3+, CD8+, and CD20+ lymphocytes were examined by immunohistochemistry in 12 PDAC patients with different outcomes who underwent pancreaticoduodenectomy. The results were correlated with the gene expression profile using the digital multiplexed NanoString nCounter analysis system (NanoString Technologies, Seattle, WA, USA). Results. Twenty immune system genes were significantly differentially expressed in patients with a good prognosis relative to patients with a worse prognosis: TLR2 and TLR7 (Toll-like receptor superfamily); CD4, CD37, FOXP3, PTPRC (B cell and T cell signalling); IRF5, IRF8, STAT1, TFE3 (transcription factors); ANP32B, CCND3 (cell cycle); BTK (B cell development); TNF, TNFRF1A (TNF superfamily); HCK (leukocyte function); C1QA (complement system); BAX, PNMA1 (apoptosis); IKBKE (NFB pathway). Differential expression was more than twice log 2 for TLR7, TNF, C1QA, FOXP3, and CD37. Discussion. Tumor infiltrating lymphocytes were present at higher levels in samples from patients with better prognosis. Our findings indicate that tumor infiltrating lymphocyte levels and expression level of the genes listed above influence pancreatic ductal adenocarcinoma prognosis. This information could be used to improve selection of best responders to immune inhibitors.

2019-06-19 | GSE132946 | GEO

Gene expression profile at single cell level of total tumor-infiltrating CD8+ T cells

Project description:Goblet cells are considered as a homogeneous population in total tumor-infiltrating CD8+ T cells. We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of total tumor-infiltrating CD8+ T cells.

2022-08-23 | GSE211690 | GEO

Characterization of immune cells infiltrating islets using scRNA-seq

Project description:Characterization of immune cells infiltrating islets using scRNA-seq

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Tumor Infiltrating Lymphocytes and Immune-Related Genes as Predictors of Outcome in Pancreatic Adenocarcinoma

Project description:Tumor Infiltrating Lymphocytes and Immune-Related Genes as Predictors of Outcome in Pancreatic Adenocarcinoma

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Autologous Tumor Infiltrating Lymphocytes MDA-TIL in Treating Patients With Recurrent or Refractory Ovarian Cancer, Colorectal Cancer, or Pancreatic Ductal Adenocarcinoma

Project description:This phase II trial studies how well autologous tumor infiltrating lymphocytes MDA-TIL works in treating patients with ovarian cancer, colorectal cancer, or pancreatic ductal adenocarcinoma that has come back (recurrent) or does not respond to treatment (refractory). Autologous tumor infiltrating lymphocytes MDA-TIL, made by collecting and growing specialized white blood cells (called T-cells) from a patient’s tumor, may help to stimulate the immune system in different ways to stop tumor cells from growing.

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scRNA-seq analysis of CD45+ cells isolated from mouse lung tumor models

Project description:Fibrocytes are defined as monocytic cells expressing collagen-1. Single-cell RNA-seq identifies a novel fibrocyte specific marker signature.

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scRNA seq analysis of CD45+ tumor infiltrating cells (TICs) of B16F10 tumor-bearing Trem1+/+ and Trem1-/- mice.

Project description:To gain a global understanding of the impact of TREM1 silencing, we analyzed the CD45+ tumor infiltrating cells (TICs) of B16F10 tumor-bearing Trem1+/+ and Trem1-/- mice. Utilizing the 10x Genomics Chromium Platform, we analyzed approximately 5390 cells per sample with a coverage rate of 15493 genes per cell.

2023-09-27 | E-MTAB-13237 | biostudies-arrayexpress

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