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Effect of COPI depletion on senescence model systems

ABSTRACT: To examine effects of COPI depletion on senescence transcriptional signatures we generated cell lines (IMR90 or IMR90 ER:RAS cells) with inducible 2 COPI shRNAs or control shRNAs and induced to senesce with either treatment with Bleomycin or 4OHT treatment. Transcriptional analysis was performed 3 days after induction of doxycycline inducible harpins and 10 days after senescence induction.

ORGANISM(S): Homo sapiens

PROVIDER: GSE224070 | GEO | 2023/09/28

REPOSITORIES: GEO

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