Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from Kimura disease patient treated with dupilumab

ABSTRACT: We performed single-cell RNA sequencing of PBMCs from Kimura disease patient succesfully treated with dupilumab to explore the mechanism of action of dupilumab treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE224144 | GEO | 2023/06/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

miR from peripheral blood mononuclear cells' (PBMCs') exosome

Project description:The results (significance versus foldchange) showed 183 up- and 195 downregulated miR in the oxygen-glucose deprivation-PBMCs compared to normoxic PBMCs

2022-12-06 | GSE190407 | GEO

Differenatiation of miRNA expression in PBMCs (peripheral blood mononuclear cells)

Project description:To determine miRNA transcribed during the PBMCs, we have employed whole genome microarray expression profiling as a discovery platform to identify miRNA expression in PBMCs donated by T1DM (type 1 diabetes mellitus) patients and healthy volunteers.

2020-06-25 | GSE133217 | GEO

Goat Peripheral Blood Mononuclear Cells (PBMCs) responses to infection vary with Peste des Petits Ruminants Virus virulence

Project description:Peste des Petits Ruminants (PPR) is a highly infectious disease caused by a virus of the genus Morbillivirus (PPRV), infecting mainly sheep and goat. Susceptibility of host can vary widely with host breed and virus strain. The mechanisms underlying this variability are not well understood. Here, we carried out the first comparative in vitro study on goat peripheral blood mononuclear cells (PBMCs) infected with PPRV strains of different virulence, vaccine strain (N75/1), low- (IC89), and high-virulent strain (MA08). Goat PBMCs were infected by the different strains and stimulated with Concanavalin A (Con A), and proteome changes of these cells were evaluated during the infection. The level of PPRV replication was assessed first by RT-qPCR quantification of viral N mRNA and by labelling the viral N protein inside the cells with specific antibodies and analysed by flow cytometry. The dynamics of PBMC sub-populations were also evaluated by flow cytometry. Our results showed that viral replication is critical for PPRV inhibitory effect on PBMCs proliferation. Highly virulent MA08 strain reached a higher level of replication in ConA-stimulated PBMCs and induced higher mortality compared to other strains. Low-virulent IC89 strain showed the lower replication level and cell proliferative inhibitory capacities. Differences in immune genes expression levels were assessed using RNAseq analysis and protein expression was compared using mass spectrometry. Analysis of these data provided the transcriptional and proteome landscape of PBMCs infected with these strains. The possible association between the transcriptional and proteome landscape and changes in immune cell subpopulations dynamics was explored.

2021-11-03 | PXD024890 | Pride

Expression data from rat peripheral blood mononuclear cells (PBMCs)

2016-08-04 | GSE85167 | GEO

Expression data from rat peripheral blood mononuclear cells (PBMCs)

Project description:The effect of cafeteria (CAF) diet in PBMC gene expression was analyzed in two inbred rat strains the Wistar Kyoto(WKY) and Lewis (LEW) rat PBMCs were isolated following a CAF or standard diet and subjected to whole genome expression analysis Rats from each strain were either fed with standard chow diet (n=5) or CAF (n=5). After 7 weeks of the indicated diet, rats were fasted for 9 hours, culled and PBMCs isolated from whole blood collected from the abdominal aorta

2016-08-04 | E-GEOD-85167 | biostudies-arrayexpress

Effects of exercise on miRNA expression in human peripheral blood mononuclear cells (PBMCs)

Project description:Exercise leads to a rapid change in the profile of gene expression in circulating PBMCs. We hypothesized that miRNA expression in circulating PBMCs would also be affected by brief exercise.

2011-09-26 | GSE28745 | GEO

Differentially expressed profile of LncRNA in PBMCs (peripheral blood mononuclear cells) of asthma patients

Project description:To determine LncRNA transcribed in PBMCs, we have employed whole genome microarray expression profiling as a discovery platform to identify LncRNA expression in PBMCs donated by patients of asthma and healthy volunteers.

2021-05-01 | GSE143192 | GEO

Differenatiation of ceRNA (circRNA, lncRNA and mRNA) expression in PBMCs (peripheral blood mononuclear cells)

Project description:To determine ceRNA transcribed during the PBMCs, we have employed whole genome microarray expression profiling as a discovery platform to identify ceRNA expression in PBMCs donated by T1DM (type 1 diabetes mellitus) patients and healthy volunteers.

2020-06-25 | GSE133225 | GEO

Comparison of gene expression profiles obtained from whole blood and peripheral blood mononuclear cells (PBMCs)

Project description:The goal of this study was to compare gene expression profiles between whole blood and PBMCs using the NanoString nCounter panCancer Immune Profiling Panel (730 endogenous genes)

2019-12-17 | GSE132006 | GEO

Single cell multi-omic sequencing (CITEseq) of human peripheral blood mononuclear cells (PBMCs)

Project description:We utilized CITESeq to investigate changes in immune cell frequencies and their transcriptomic signatures in PBMCs obtained from subjects with low and high coronary artery disease (CAD) severity quantified using gensini scoring system as well as subjects with and without IgE to alpha-gal sensitization

2022-02-02 | GSE190570 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data