Single cell and spatial transcriptomic profile of whole CLAD and donor control lung tissue

ABSTRACT: Chronic lung allograft dysfunction (CLAD) is the leading cause of death in lung transplant recipients. CLAD is characterized clinically by a persistent decline in pulmonary function and histologically by the development of airway centered fibrosis known as bronchiolitis obliterans. We performed single-cell sequencing and spatial transcriptomic analysis of explanted tissues from human lung recipients with CLAD and donor control lungs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE224210 | GEO | 2023/03/21

REPOSITORIES: GEO