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RNA-sequencing in mESCs with overexpression of mCherry-tagged DUX and DUX domain derivatives

ABSTRACT: To investigate the requirement of DUX domains for target gene expression, we created clonal stable cell lines in Dux-/- mouse embryonic stem cells and expressed constructs for 12 hours with 0.25 ug/mL doxycycline We then performed gene expression profiling analysis using data obtained from RNA-seq of 11 different cell lines at one time point

ORGANISM(S): Mus musculus

PROVIDER: GSE224296 | GEO | 2023/08/07

REPOSITORIES: GEO

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Assessment of functional overlap between mouse Dux and human DUX4 in vitro and in vivo

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