Transcriptomics

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Single cell analysis reveals immune subtypes associated with CRT treatment


ABSTRACT: Cervical cancer (CC) is one of the most prevalent female malignancies globally in low- and middle-income regions, accounting for 7.5% of all female cancer deaths.Despite advancements in medical technology and treatment protocols,the combination of radiation therapy and chemotherapy, known as chemoradiotherapy (CRT), remains the standard of care for locally advanced cervical cancer. However, a substantial proportion of patients do not achieved a complete response to CRT, leading to treatment failure and poor clinical outcomes.Herein, we profiled the transcriptome of 50649 cells derived from six partial responsive(PR) tumor tissues and two complete responsive(CR) tissues of CSCC through scRNA-seq. We displayed a comprehensive cell landscape of the TME and investigated its function and lineage tracking.

ORGANISM(S): Homo sapiens

PROVIDER: GSE224327 | GEO | 2025/06/16

REPOSITORIES: GEO

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