The MMP-2 histone H3 N-terminal tail protease is selectively targeted to the transcription start sites of active genes [ChIP-seq]

ABSTRACT: Our study examines the role of MMP-2 mediated Histone H3NT proteolysis in U2OS cells. We find binding of MMP-2 at all active protein coding transcription start sites, and examine the role it plays in local chromatin regulation and changes in gene expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE224886 | GEO | 2023/05/05

REPOSITORIES: GEO