Dominant-negative HNF1α mutant promotes liver steatosis and inflammation by regulating hepatic complement factor D

ABSTRACT: Heterozygous mutations of HNF1A gene are the pathogenic cause of MODY3. A few studies reported that MODY3 patients may have dyslipidemia and early onset of liver steatosis in some cases. However, there is a lack of sufficient and reliable experimental evidence on how HNF1α regulates NAFLD progression under the genetic background of MODY3. We established a novel mouse model carrying the dominant-negative human HNF1α P291fsinsC mutation (termed as hHNF1Amut/- mice). The hepatic morphological phenotypes and the changes of lipid metabolism were investigated. To reveal the molecular changes, we performed the transcriptome and proteome analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE224953 | GEO | 2023/08/09

REPOSITORIES: GEO