RPS19 binding with and without Diamond-Blackfan anemia variants

ABSTRACT: We found that endogenously expressed RPS19 binds evolutionarily constrained intronic elements. By assessing overexpression of WT RPS19 and RPS19 harboring the most common Diamond-Blackfan anemia missense mutations, we confirmed that disease-relevant mutations alter RPS19 binding preferences in human cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE224998 | GEO | 2023/02/14

REPOSITORIES: GEO