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MYC confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma

ABSTRACT: To investigate the effect of CDK12/13 inhibition and MYC over-expression on gene expression of high-risk Group 3 medulloblastoma cells, we established D341 cells treated or not with 100 nM THZ531 for 6 hours and silenced (siMYC) or not (siCtrl) for MYC expression for 48 hrs, respectively.

ORGANISM(S): Homo sapiens

PROVIDER: GSE225375 | GEO | 2023/09/13

REPOSITORIES: GEO

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