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Cardiac Effects of Rosiglitazone in Male Wistar Rats

ABSTRACT: Rosiglitazone, a peroxisome proliferator-activated receptor g (PPARg) agonist of the thiazolidinedione class, is a major insulin-sensitizing drug widely used to treat type-2 diabetes. Rosiglitazone causes myocardial hypertrophy in rodents and increases the risk of cardiac events in man. To better characterize its cardiac effects, male Wistar rats were orally administered 0, 10 or 80 mg/kg/day rosiglitazone.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE22553 | GEO | 2010/06/25

SECONDARY ACCESSION(S): PRJNA128455

REPOSITORIES: GEO

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Cardiac Effects of Rosiglitazone in Male Wistar Rats

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