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Activation of GPCR-GNAS-PKA signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity

ABSTRACT: To investigate the machanism by which MC1R represses the expression of a subset of IFNg reponsvie genes. We then performed ATAC seq and H3K27ac ChIP-seq to identify promoter and enhancer of MC1R-repressed IFNg reponsive genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE225553 | GEO | 2023/08/09

REPOSITORIES: GEO

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Activation of GPCR-GNAS-PKA signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity

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