Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Hnf4 controls gut and liver gene programs in the thymus [CUT&Tag]

ABSTRACT: We profiled medullary thymic epithelial cells and intestinal epithelial cells by CUT&Tag to investigate mechanisms of T-cell tolerance.

ORGANISM(S): Mus musculus

PROVIDER: GSE225658 | GEO | 2023/06/26

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Hnf4 controls gut and liver gene programs in the thymus [CUT&RUN]

Project description:We profiled medullary thymic epithelial cells by CUT&RUN to investigate mechanisms of T-cell tolerance.

2023-06-26 | GSE225657 | GEO

Hnf4 controls gut and liver gene programs in the thymus [scRNAseq]

Project description:We profiled medullary thymic epithelial cells by scRNA-seq to investigate mechanisms of T-cell tolerance.

2023-06-26 | GSE225660 | GEO

Hnf4 controls gut and liver gene programs in the thymus [bulk_RNAseq]

Project description:We profiled medullary thymic epithelial cells by bulk RNA-seq to investigate mechanisms of T-cell tolerance.

2023-06-26 | GSE225659 | GEO

Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells [CUT&TAG]

Project description:We profiled medullary thymic epithelial cells by CUT&Tag to investigate mechanisms of T-cell tolerance.

2022-06-16 | GSE194231 | GEO

Z-DNA underlies the target choice of Aire by facilitating promoter poising [CUT&Tag]

Project description:We profiled Pol II-pS5 binding in medullary thymic epithelial cells using CUT&Tag to investigate the logic of Aire's target choices

2024-03-11 | GSE224555 | GEO

Hnf4 controls gut and liver gene programs in the thymus

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-06-26 | GSE225661 | GEO

Insm1 regulates the expression of thymic tissue-restricted antigens and the immune tolerance [CUT&Tag]

Project description:Insm1, encoding a zinc finger protein, is expressed specifically in neuroendocrine cells. Recent study showed the first evidence of Insm1 expression in medullary thymic epithelial cells (mTEC). Here we investigated the expression and function of Insm1 in mTEC. Mutation of Insm1 resulted in decreased proportion of mTEChi although normal development of other types of thymic cells. We detected altered expression of a subset of tissue-restricted antigens (TRAs) and mild decreased expression of Aire and Fezf2 in Insm1 mutant mTEC. We further showed that Insm1 recognizes a DNA sequence which is similar to the CCCTC-Binding factor (CTCF) binding motif. Mutation of Insm1 altered CTCF binding genome widely and thus the expression of genes. In nude mice transplanted with Insm1 mutant thymus, autoimmune responses were observed in multiple peripheral tissues. In thymus specific Insm1 mutant mice, we detected decreased induction of regulatory T (Treg) cells in the thymus, obvious lymphocytes infiltration and autoimmune antibody reaction in several peripheral tissues. In thymic epithelial cells specific Insm1 overexpression mice, we detected enlarged mTEC proportion and increased expression of mTEC specific genes. Thus, we suggest that Insm1 is a novel regulator of mTEC function and autoimmunity.

2024-01-01 | GSE193926 | GEO

CUT&TAG of OE19 cell line

Project description:To map the chromatin binding sites for various factors in OE19 cells, we performed CUT&TAG.

2023-02-24 | E-MTAB-11356 | biostudies-arrayexpress

Bulk Cut&run and Cut&tag

Project description:Bulk Cut&run and Cut&tag

| PRJNA686390 | ENA

Gene expression in the thymus medulla in the absence and presence of acute graft-versus-host disease

Project description:To investigate gene expression profile of medullary thymic epithelial cells with high surface density of MHC class II (mTEChigh), a murine parent into F1 hematopoietic stem cell transplantation model was administered. As recipient mice (B6xDBA/2)F1 (B6D2F1) were used that received either a syngeneic transplant from a (B6xDBA/2)F1 mouse or an allogeneic transplant from a B6 mouse, which leads to acute graft-versus-host disease (aGVHD). mTEChigh (CD45-EpCAM+Ly51-UEA1+MHCIIhigh) are sorted by FACS.

2012-12-20 | E-MEXP-3745 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data