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Hnf4 controls gut and liver gene programs in the thymus [scRNAseq]

ABSTRACT: We profiled medullary thymic epithelial cells by scRNA-seq to investigate mechanisms of T-cell tolerance.

ORGANISM(S): Mus musculus

PROVIDER: GSE225660 | GEO | 2023/06/26

REPOSITORIES: GEO

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Hnf4 controls gut and liver gene programs in the thymus [bulk_RNAseq]

Project description:We profiled medullary thymic epithelial cells by bulk RNA-seq to investigate mechanisms of T-cell tolerance.

2023-06-26 | GSE225659 | GEO

Hnf4 controls gut and liver gene programs in the thymus [CUT&RUN]

Project description:We profiled medullary thymic epithelial cells by CUT&RUN to investigate mechanisms of T-cell tolerance.

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Hnf4 controls gut and liver gene programs in the thymus [CUT&Tag]

Project description:We profiled medullary thymic epithelial cells and intestinal epithelial cells by CUT&Tag to investigate mechanisms of T-cell tolerance.

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Hnf4 controls gut and liver gene programs in the thymus

Project description:This SuperSeries is composed of the SubSeries listed below.

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Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells [scRNA-seq]

Project description:We profiled medullary thymic epithelial cell subsets from a variety of conditions by scRNA-seq to investigate mechanisms of T-cell tolerance.

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Comparison of RelB-/- and RelB+/- thymi

Project description:Thymic medullary epithelial cell (mTEC) expression of the autoimmune regulator AIRE, and of tissue-specific antigens, is controlled by members of the non-canonical NF-kB signalling pathway, including RelB and NF-kB2. Of the genes in this pathway, RelB-/- mice develop a particularly severe multi-organ autoimmune syndrome, resembling Foxp3-deficiency. RelB-/- mice have medullary atrophy and few mTECs but the mechanism is unknown. We show that RelB is required for expression of medullary chemokines and mTEC AIRE, selection of a diverse peripheral T cell repertoire, and for peripheral Foxp3+ Treg function. VÎ² families of T cells infiltrating diseased peripheral organs and thymic Treg were similarly skewed. Surprisingly, medullary atrophy results from intra-thymic granulocyte infiltration, consequent upon the Th2-mediated autoimmune disease. Dominant tolerance corrects thymic inflammatory disease and loss of thymic function. We demonstrate a reversible RelB-dependent inflammatory mechanism for loss of central tolerance associated with medullary atrophy. Thymi from 4 RelB+/- mice and 3 RelB-/- mice were profiled by microarays

2012-12-27 | E-GEOD-43154 | biostudies-arrayexpress

Comparison of RelB-/- and RelB+/- thymi

Project description:Thymic medullary epithelial cell (mTEC) expression of the autoimmune regulator AIRE, and of tissue-specific antigens, is controlled by members of the non-canonical NF-kB signalling pathway, including RelB and NF-kB2. Of the genes in this pathway, RelB-/- mice develop a particularly severe multi-organ autoimmune syndrome, resembling Foxp3-deficiency. RelB-/- mice have medullary atrophy and few mTECs but the mechanism is unknown. We show that RelB is required for expression of medullary chemokines and mTEC AIRE, selection of a diverse peripheral T cell repertoire, and for peripheral Foxp3+ Treg function. Vβ families of T cells infiltrating diseased peripheral organs and thymic Treg were similarly skewed. Surprisingly, medullary atrophy results from intra-thymic granulocyte infiltration, consequent upon the Th2-mediated autoimmune disease. Dominant tolerance corrects thymic inflammatory disease and loss of thymic function. We demonstrate a reversible RelB-dependent inflammatory mechanism for loss of central tolerance associated with medullary atrophy.

2012-12-27 | GSE43154 | GEO

Transposable elements regulate T cell maturation and education in the thymus

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2024-04-16 | GSE232011 | GEO

Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells [CUT&TAG]

Project description:We profiled medullary thymic epithelial cells by CUT&Tag to investigate mechanisms of T-cell tolerance.

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Project description:We profiled medullary thymic epithelial cells from AireWT vs AireKO mice by scATAC-seq to investigate mechanisms of T-cell tolerance.

2022-06-16 | GSE194233 | GEO

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