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Effect of constitutive AHR activation in skeletal muscle [AHRmKO_RNAseq]

ABSTRACT: To investigate the RNA differences in skeletal muscle in muscle-specific AHR (aryl hydrocarbon receptor) knockout mice and their AHR-floxed littermate controls (wildtype) following a 16-week chronic cigarette smoke exposure intervention

ORGANISM(S): Mus musculus

PROVIDER: GSE225670 | GEO | 2024/02/20

REPOSITORIES: GEO

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Effect of bone marrow-specific aryl hydrocarbon receptor (Ahr) gene knockout on expression profiles of hematopoietic stem cells from young and old mice.

Project description:As part of a study of the role of the aryl hydrocarbon receptor (Ahr) in maintenance and senescence of hematopoietic stem cells (HSC), global gene expression profiling was done with HSC isolated from bone marrow restricted conditional Ahr-knockout and AhR floxed mice. HSC from young-adult (8 wk old) cAhR-KO mice had changes in expression of many genes related to HSC maintenance, consistent with the phenotype observed in Ahr-KO mice. Aged cAhR-KO mice (18 months old) also displayed alterations in peripheral white blood cell counts, serial repopulation potential and levels of ROS in bone marrow cells, consistent with previous observations on the role of AhR in the hematopoietic system. 22 samples: 5 young Ahr knockout, 6 old Ahr knockout, 5 young floxed Ahr, 6 old floxed Ahr

2016-06-30 | E-GEOD-76276 | biostudies-arrayexpress

Microarray analysis of CA-AhR transgenic mice

2010-02-01 | GSE19518 | GEO

Microarray analysis of CA-AhR transgenic mice

Project description:We have generated transgenic mice expressing constitutively activated aryl hydrocarbon receptor (CA-AhR) to examine the biological consequences of AhR activation.. We used microarrays to identify genes that are regulated by AhR. Livers or intestines from three female mice were pooled at 5-6 week-old for RNA extraction and hybridization on Affymetrix Mouse Genome 430 2.0 Array.

2010-02-01 | E-GEOD-19518 | biostudies-arrayexpress

Proteome and Phosphoproteome of AhR-dependent non-genomic signaling in endotoxin-activated macrophages

Project description:Emerging studies revealed an immunomodulatory role of the Aryl hydrocarbon receptor (AhR), a receptor sensing environmental contaminants, and involved in their detoxification. Besides its function as a transcription factor, AhR can participate in non-genomic signaling through ubiquitination and phosphorylation-dependent processes. In this study, a multi-PTM-omics approach, including proteome, ubiquitome, and phosphoproteome, was utilized to examine mechanisms of non-genomic AhR-signaling in endotoxin-activated monocyte-derived macrophages. This dataset entails proteome and phosphoproteome data.

2021-03-30 | PXD020770 | Pride

AhR interactome in early embryonic development

Project description:The transcriptional program of early embryonic development is tightly regulated by a set of well-defined transcription factors that suppress premature expression of differentiation genes and sustain the pluripotent identity. It is generally accepted that this program can be perturbed by environmental factors such as chemical pollutants, however the precise molecular mechanisms remain unknown. The Aryl Hydrocarbon Receptor (AHR) is a widely expressed nuclear receptor that senses environmental stimuli and modulates target gene expression. Here, we show that ectopic activation of AHR during early differentiation disrupts the differentiation program via the chromatin remodeling complex NuRD. The activated AHR/NuRD complex altered the expression of differentiation-specific genes that control the first two developmental decisions without affecting the pluripotency program. These findings identify a novel mechanism that allows environmental stimuli to disrupt embryonic development through AHR signaling.

2018-02-26 | PXD006089 | Pride

Differential Genome Expression in AhR-KD and Control HCMV-Infected Fibroblasts

Project description:Here we report the effect of Aryl hydrocarbon Receptor (AhR) on the transcriptome of HCMV-infected fibroblasts.

2021-03-05 | GSE159375 | GEO

Transcriptome profiles of colonic stem cells of WT and AHR deficient mice treated with either DMSO or high affinity AHR ligand, FICZ for 4 hours

Project description:To identify aryl hydrocarbon receptor (AHR) dependent transcriptional changes in mouse colon stem cells, we performed RNA sequencing of colon organoids from wildtype and AhR deficient mice stimulated with an high affinity AHR ligand, 5nM FICZ for 4 hours.

2022-02-09 | GSE179481 | GEO

Cryo-EM structure of the cytosol AhR complex

Project description:Aryl hydrocarbon receptor (AhR) is an important ligand-activated transcription factor involved in the regulation of various important physiological functions. AhR can be activated by a variety of signals with different affinities, including xenobiotics and endogenous signals. In the absence of ligand, AhR forms a stable multiprotein complex in the cytosol with the chaperone Hsp90 and co-chaperon p23, XAP2.

2022-12-26 | PXD038120 | JPOST Repository

AhR mediated changes in the murine lung dendritic cell transcriptome

Project description:Analysis of gene expression in isolated mouse lung dendritic cells isolated during influenza A virus infection, with and without activaiton of the aryl hydrocarbon receptor (AHR).

2018-12-18 | GSE123996 | GEO

Effect of bone marrow-specific aryl hydrocarbon receptor (Ahr) gene knockout on expression profiles of hematopoietic stem cells from young and old mice.

2016-06-30 | GSE76276 | GEO

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