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Effect of p53 knockout on gene expression during capmatinib treatment of NF1-MET murine MPNST cells

ABSTRACT: To investigate the function of p53 in regulating response to MET inhibition in MPNST cells we established NF1-MET;sgP53 cells in which Trp53 was knocked out using CRISPR-Cas9. As a control, the parental NF1-MET was transduced with CRISPR-Cas9 in the absence of sgRNA. We then performed gene expression profiling analysis using data obtained from RNA-seq of the 2 different cells treated with either capmatinib or vehicle in duplicate.

ORGANISM(S): Mus musculus

PROVIDER: GSE225747 | GEO | 2024/03/14

REPOSITORIES: GEO

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