Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted anti-cancer therapy

ABSTRACT: Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted anti-cancer therapy

ORGANISM(S): Homo sapiens

PROVIDER: GSE225775 | GEO | 2023/03/10

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Tiling path analysis of a comprehensive assay for targeted multiplex amplification of human DNA sequences

Project description:Multiplex amplification of human sequences using SMART technology

2008-07-26 | E-MEXP-1638 | biostudies-arrayexpress

Bambusa multiplex

Project description:Bambusa multiplex overview

| PRJNA399780 | ENA

Massively multiplex chemical transcriptomics at single cell resolution

Project description:Massively multiplex chemical transcriptomics at single cell resolution

| PRJNA587707 | ENA

Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for amyotrophic lateral sclerosis and frontotemporal dementia (Multiplex Analysis of PolyA-linked Sequences)

Project description:Purpose: The purpose of this experiment is to identify a C9-ALS/FTD specific genomic profile in fibroblast lines that is distinct from sporadic ALS without C9orf72 expansion and non-neurologic control cells. The study will then evaluate the effect on this identified profile of ASO treatment targeting the sense strand RNA transcript of the C9orf72 gene. Methods: Expression profiling was performed on RNAs from fibroblasts of four C9orf72 patients, four control individuals and four sporadic ALS patients using Multiplex Analysis of PolyA-linked Sequences method. Results: Hierarchical clustering of expression values for all genes showed that the four C9orf72 patient lines had an expression profile distinct from control and sporadic ALS lines. Statistical comparison of expression values between the four C9orf72 lines and the four control lines revealed that 122 genes were upregulated (defined by a False Discovery Rate FDR<0.05) and 34 genes were downregulated (defined by a False Discovery Rate FDR <0.05) in C9orf72 patient fibroblasts. Conclusions: A genome wide RNA signature can be defined in fibroblasts with C9orf72 expansion. ASO-mediated reduction of C9orf72 RNA levels in fibroblasts with the hexanucleotide expansion efficiently reduced accumulation of GGGGCC RNA foci. This did not, however, generate a reversal of the C9orf72 RNA profile. Use of Multiplex Analysis of PolyA-linked Sequences to identify expression changes in fibroblasts from amyotrophic lateral sclerosis and frontotemporal dementia patients harboring an hexanucleotide expansion in the C9orf72 gene.

2013-11-12 | E-GEOD-51684 | biostudies-arrayexpress

Survival and PN Dependence in SBS Patients

Project description:Short bowel syndrome (SBS) is a rare condition resulting from the loss of portions of the small intestine, and can cause a spectrum of metabolic and physiologic disturbances.The objective of this study was to determine the longterm survival and parenteral nutrition dependence of adult patients with SBS.

| 114861 | ecrin-mdr-crc

Antisocial Drug Dependence

Project description:Antisocial Drug Dependence

| PRJNA547655 | ENA

Antisocial Drug Dependence

Project description:Antisocial Drug Dependence

| PRJNA547656 | ENA

CIDR Alcohol Dependence

Project description:CIDR Alcohol Dependence

| PRJNA75517 | ENA

275bp Artic multiplex evaluation

Project description:275bp Artic multiplex evaluation