Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tissue-resident, extravascular Ly6c- monocytes are critical for inflammation in the synovium Figure 3 & 7

ABSTRACT: Identification of intra- and extra- vascular Syn Ly6c- cells

ORGANISM(S): Mus musculus

PROVIDER: GSE225801 | GEO | 2023/08/15

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Tissue-resident, extravascular Ly6c- monocytes are critical for inflammation in the synovium Figure 2 & 7

Project description:scRNA-seq analysis of joint myeloid niche identifies tissue Syn Ly6c- cells.

2023-08-15 | GSE225800 | GEO

Tissue-resident, extravascular Ly6c- monocytes are critical for inflammation in the synovium Figure 1

Project description:Synovial Ly6c- cells are phenotypically distinct from circulating NCM

2023-08-15 | GSE225799 | GEO

Tissue-resident, extravascular Ly6c- monocytes are critical for inflammation in the synovium Figure 4

Project description:Extra-vascular tissue location confers phenotype of TR-MC

2023-08-15 | GSE225802 | GEO

Tissue-resident, extravascular Ly6c- monocytes are critical for inflammation in the synovium

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-08-15 | GSE225803 | GEO

Genomic characterization of murine monocytes reveals C/EBPb dependence of Ly6C-cells [ChIP data]

Project description:Chromatin status of murine blood Ly6C+ and Ly6C- monocytes indicates that both population share K4me3 marks (promoters) while Ly6C- monocytes establish de novo enhancers (K4me1, K4me2) during differentiation

2017-05-15 | GSE95409 | GEO

Genomic characterization of murine monocytes reveals C/EBPb dependence of Ly6C-cells [RNA sequence]

Project description:We show that monocyte development is accompanied by stepwise RNA expression changes and that Ly6C+ monocytes upon transfer develop into Ly6C- monocytes indicated by a comparable expression profile to host Ly6C- monocytes

2017-05-15 | GSE95411 | GEO

AffyExon1 genearray expression profile of adult mouse microglia and splenic Ly6C monocytes

Project description:Gene profiling of CNS-derived microglia vs splenic CD11b+Ly6C+ monocyte subsets deom adult mice Gene array identified 1572 genes that were enriched in microglia vs. 611 monocyte enriched genes with a greater than 5-fold difference (P<0.001). Gene profiling of CD11b+CD45Low microglia isolated from the CNS and CD11b+Ly6C+ monocyte subsets isolated from the spleen of naM-CM-/ve adult mice.

2013-07-08 | E-GEOD-48579 | biostudies-arrayexpress

Expression arrays of inflammatory Ly6C+ monocytes in mice primary or secondary challenged with Listeria monocytogenes

Project description:In this study we investigated the mechanisms involved in memory T-cell mediated protection using mice vaccinated with the intracellular bacterium Listeria monocytogenes. Our working hypothesis was that rapid activation of cells of the innate immune system, in particular inflammatory Ly6C+ monocytes, were essential in effective protection, in a memory T cell-dependent manner. Thus we generated a comprehensive comparison of the genetic program of activated Ly6C+ monocytes during a primary or a secondary infection with Listeria monocytogenes, at 8 hours post challenge infection. Abstract of corresponding publication: Cells of the innate immune system are essential for host defenses against primary microbial pathogen infections, yet their involvement in effective memory responses of vaccinated individuals has been poorly investigated. Here we show that memory T cells instruct innate cells to become potent effector cells in a systemic and a mucosal model of infection. Memory T cells controlled phagocyte, dendritic cell and NK or NK T cell mobilization and induction of a strong program of differentiation, which included their expression of effector cytokines and microbicidal pathways, all of which were delayed in non-vaccinated hosts. Disruption of IFN-gamma-signaling in Ly6C+ monocytes, dendritic cells and macrophages impaired these processes and the control of pathogen growth. These results reveal how memory T cells, through rapid secretion of IFN-gamma, orchestrate extensive modifications of host innate immune responses that are essential for effective protection of vaccinated hosts. Overall design: Inflammatory monocytes were purified (see below for isolation method) from 4 groups of 3 individual mice each (triplicate): (i) uninfected mice, (ii) primary infected, (iii) secondary infected, (iv) secondary infected and T-cell depleted 1 day before. Isolation of cells was done on 3 different days for true biological replicates.

2015-06-04 | E-GEOD-58014 | biostudies-arrayexpress

RNA-seq of sorted mouse gdT cell populations based on TCR Vg chain and Ly6C status

Project description:Gamma-delta (gd) T cells from pooled mouse lymph nodes and spleens were isolated and FACS-sorted for Vg1+Ly6C-, Vg1+Ly6C+, Vg4+Ly6C- and Vg4+Ly6C+ subsets of bulk CD27+ gdT cells.

2024-04-16 | E-MTAB-13897 | biostudies-arrayexpress

Expression data from mouse circulating Ly6C-low subset of monocytes (patrolling monocytes)

Project description:Expression data from mouse circulating Ly6C-low subset of monocytes (patrolling monocytes)

| PRJNA632620 | ENA