Transcriptomics

Dataset Information

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Brain rhythms control microglial response and cytokine expression via NFkB signaling


ABSTRACT: Microglia, the brain’s primary immune cells, transform in response to changes in sensory or neural activity, like sensory deprivation. However, little is known about how specific frequencies of neural activity, impact microglia, immune signaling, or other pathways within the brain. Here , we exposed mice to 1h of audio/visual noninvasive flickering sensory stimulation (flicker) to induce electrical neural activity at different frequencies: 40Hz within the gamma band and 20Hz within the beta band. We then isolated RNA from the visual cortices and used bulk RNAseq to quantify pathway changes.

ORGANISM(S): Mus musculus

PROVIDER: GSE225842 | GEO | 2023/06/15

REPOSITORIES: GEO

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