Genomics

Dataset Information

0

Understanding cancer drug resistance with Sleeping Beauty functional genomic screens: application to MAPK inhibition in cutaneous melanoma

ABSTRACT: To determine how VAV1 drives drug resistance to BRAFi, we overexpressed VAV1 in A375 and compared these cells to A375 overexpressing RAC1P29S. We also determined the impact of SRCi on the transcriptional program elicited by VAV1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE226664 | GEO | 2023/03/09

REPOSITORIES: GEO

Json Xml

Similar Datasets

Unknown Sequencing methods and datasets to improve functional interpretation of sleeping beauty mutagenesis screens.
| S-EPMC4378557 | biostudies-literature
Transcriptomics Gene expression profiling of isogenic malignant melanoma A375-BRAFV600E/NRASQ61 and A375-BRAFV600E/NRASQ61K cell lines
2021-09-23 | GSE184633 | GEO
Unknown RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens.
| S-EPMC4691744 | biostudies-literature
Unknown Characterization of Sleeping Beauty transposition and its application to genetic screening in mice.
| S-EPMC309709 | biostudies-literature
Genomics Sleeping Beauty ILC screen
| PRJEB14134 | ENA
Transcriptomics Sleeping Beauty Expression data from mouse
2016-07-03 | E-GEOD-43263 | biostudies-arrayexpress
Unknown Sleeping beauty transposition from nonintegrating lentivirus.
| S-EPMC2835211 | biostudies-literature
Transcriptomics Sleeping Beauty Expression data from mouse
2016-01-01 | GSE43263 | GEO
Unknown Structural Determinants of Sleeping Beauty Transposase Activity.
| S-EPMC5010145 | biostudies-literature
Transcriptomics Gene expression data from murine cutaneous squamous cell carcinoma genomes induced by Sleeping Beauty transposon mutagenesis
2021-07-29 | GSE141167 | GEO