Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data from mothers, placentas, and newborns in the Democratic Republic of Congo

ABSTRACT: Maternal stress has long been associated with lower birthweight but mechanisms remain elusive. This study explored how maternal stress may impact changes in gene expression within a cohort of mother-placenta-newborn triads in the eastern Democratic Republic of Congo We used microarrays to detail the global programme of gene expression underlying the impact of maternal stress on newborn birthweight and identified that global placental gene expression may partially mediate the negative impact of maternal war stress on newborn birthweight.

ORGANISM(S): Homo sapiens

PROVIDER: GSE226993 | GEO | 2023/03/10

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Epigenetic analysis of psychosocial stress among mother-newborn dyads in the Democratic Republic of Congo (EAA)

Project description:Prenatal maternal stress has a negative impact on child health but the mechanisms through which maternal stress affects child health are unclear. Epigenetic variation, such as DNA methylation, is a likely mechanistic candidate as DNA methylation is sensitive to environmental insults and can regulate long-term changes in gene expression. We recruited mother-newborn dyads in the Democratic Republic of Congo to investigate the effects of maternal stress on DNA methylation in mothers and newborns. We used four measures of maternal stress to capture a range of stressful experiences: general trauma, sexual trauma, war trauma, and chronic stress. We identified differentially methylated positions (DMPs) associated with general trauma, sexual trauma, and war trauma in both mothers and newborns. No DMPs were associated with chronic stress. Sexual trauma was positively associated with epigenetic age acceleration across several epigenetic clocks in mothers. General trauma and war trauma were positively associated with newborn epigenetic age acceleration using the extrinsic epigenetic age clock. We tested the top DMPs for enrichment of DNase I hypersensitive sites (DHS) and found no enrichment in mothers. In newborns, top DMPs associated with war trauma were enriched for DHS in embryonic and fetal cell types. Finally, one of the top DMPs associated with war trauma in newborns also predicted birthweight, completing the cycle from maternal stress to DNA methylation to newborn health outcome. Our results indicate that maternal stress is associated with site-specific changes in DNAm and epigenetic age acceleration in both mothers and newborns.

2023-06-08 | GSE224363 | GEO

Epigenetic analysis of psychosocial stress among mother-newborn dyads in the Democratic Republic of Congo (EWA reanalysis)

2023-06-08 | GSE224364 | GEO

Longitudinal analysis of birthweight and epigenetic aging among children from birth to age three in the Democratic Republic of Congo

Project description:Genome-wide DNA methylation profiling of venous blood samples from children in the Eastern Democratic Republic of Congo from birth to age three. DNA methylation data were noob normalized and uploaded to Steve Horvath's epigenetic age calculator website to calculate Horvath epigenetic age acceleration for each participant at each timepoint for which they had data available. Replicates were averaged and a single outlier at birth was removed as described in the manuscript, leaving 155 observations from 67 unique individuals. Sample size at each timepoint was as follows: n = 64 at birth, n = 8 at six months, n= 35 at one year, n = 32 at two years, and n = 16 at three years.

2023-06-26 | GSE224573 | GEO

WGS of S. aureus from the Democratic Republic of Congo

Project description:Whole genome sequencing of S. aureus from the Democratic Republic of Congo

| PRJEB15192 | ENA

multidrug-resistant Escherichia coli in the Democratic Republic of Congo

Project description:Whole-genome sequences of multidrug-resistant Escherichia coli in South-Kivu Province, Democratic Republic of Congo: characterization of phylogenomic changes, virulence and resistance genes

| PRJEB21637 | ENA

Genomic study of seventh pandemic Vibrio cholerae El Tor isolates from the Democratic Republic of Congo

Project description:Genomic study of seventh pandemic Vibrio cholerae El Tor isolates from the Democratic Republic of Congo

| PRJEB47296 | ENA

Anopheles funestus pooled template whole genome sequencing of field-collected mosquitoes (from Democratic Republic of Congo and Mozambique).

Project description:Anopheles funestus pooled template whole genome sequencing of field-collected mosquitoes (from Democratic Republic of Congo and Mozambique).

| PRJEB33149 | ENA

Czech Republic human listeriosis

Project description:Czech Republic human listeriosis

| PRJEB37840 | ENA

Genomic analysis of pathogenic strains of Vibrio cholerae from the Democratic Republic of Congo (2014-2017)

Project description:Whole genome sequencing (WGS) was carried out on 78 V. cholerae clinical isolates characterized phenotypically and associated with cholera in eastern provinces of the Democratic Republic of Congo between 2014 and 2017

| PRJEB32089 | ENA

Illumina Omni2.5-Octo BeadChip data from 55 Fulani individuals from Ziniare, Burkina Faso and 7 Czechs & Slovaks collected in Prague, Czech Republic.

Project description:Genotype data from 55 Fulani individuals from Ziniare, Burkina Faso and 7 Czechs & Slovaks collected in Prague, Czech Republic The data was typed in Illumina Omni2.5-Octo BeadChip.

2019-11-12 | E-MTAB-8434 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data