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Aging-induced Suppression of Cirbp Compromises DHODH-Mediated Ferroptosis Defense and Attenuates Hypothermic Cardioprotection during Heart Transplantation [RNA-seq]

ABSTRACT: The purpose of this study was to explore the potential mechanism of attenuated hypothermic cardioprotection in the aging donor heart during transplantation and investigate its translational values.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE227004 | GEO | 2026/03/05

REPOSITORIES: GEO

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Aging-induced Suppression of Cirbp Compromises DHODH-Mediated Ferroptosis Defense and Attenuates Hypothermic Cardioprotection during Heart Transplantation [ChIP-seq]

Project description:The purpose of this study was to explore the potential mechanism of attenuated hypothermic cardioprotection in the aging donor heart during transplantation and investigate its translational values. We performed chromatin occupancy of Sp1 profiling analysis using data obtained from chromatin immunoprecipitation-sequencing (ChIP-seq) of LV myocardium from the wild-type rat

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Aging-induced Suppression of Cirbp Compromises DHODH-Mediated Ferroptosis Defense and Attenuates Hypothermic Cardioprotection during Heart Transplantation

Project description:Aging-induced Suppression of Cirbp Compromises DHODH-Mediated Ferroptosis Defense and Attenuates Hypothermic Cardioprotection during Heart Transplantation

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Aging-induced Suppression of Cirbp Compromises DHODH-Mediated Ferroptosis Defense and Attenuates Hypothermic Cardioprotection during Heart Transplantation

Project description:This SuperSeries is composed of the SubSeries listed below.

2026-03-05 | GSE227005 | GEO

Aging-induced Suppression of Cirbp Compromises DHODH-Mediated Ferroptosis Defense and Attenuates Hypothermic Cardioprotection during Heart Transplantation [ChIP-seq]

Project description:Aging-induced Suppression of Cirbp Compromises DHODH-Mediated Ferroptosis Defense and Attenuates Hypothermic Cardioprotection during Heart Transplantation [ChIP-seq]

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Transcriptional profiling of pig striatum after deep hypothermic cardiac arrest

Project description:The goal of the study was to identify the gene changes that occur in the striatum of neonatal piglets exposed to cardiopulmonary bypass (CPB) with deep hypothermic cardiac arrest (DHCA) then recovered for 6h. To accomplish our goal, mRNA-seq was performed on RNA isolated from neonatal pigs exposed to either DHCA or sham conditions.

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Project description:Background/objectiveWe aimed to elucidate the roles of ferroptosis-associated differentially expressed genes (DEGs) in glioblastoma and provide a comprehensive resource for researchers in the field of glioblastoma cell ferroptosis.MethodsWe used RNA sequencing to identify the DEGs associated with erastin-induced ferroptosis in glioblastoma cells. We further unraveled the biological functions and clinical implications of cold-inducible RNA-binding protein (CIRBP) in the context of glioblastoma by using a multifaceted approach, encompassing gene expression profiling, survival analysis, and functional assays to elucidate its role in glioblastoma cell mortality and its potential influence on patient prognosis.ResultsWe identified and validated the gene encoding CIRBP, the expression of which is altered during glioblastoma ferroptosis. Our findings highlight the relationship between CIRBP expression and ferroptosis in glioblastoma cells. We demonstrated that CIRBP modulates key aspects of cell death, thereby altering the sensitivity of glioblastoma cells to erastin-induced ferroptosis. A prognostic model, constructed based on CIRBP expression levels, revealed an association between lower CIRBP levels and poorer prognosis in glioma patients; this finding was corroborated by our comprehensive in vitro and in vivo assays that highlighted the impact of modulating CIRBP expression on glioblastoma cell viability and ferroptotic response.ConclusionOur research unravels the complex molecular dynamics of ferroptosis in glioblastoma and underscores CIRBP as a potential biomarker and therapeutic target. This improved understanding of the role of CIRBP in ferroptosis paves the way for more precise and efficacious treatments for glioblastoma, potentially improving patient outcomes.

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