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The effects of YTHDC1 on liver function [YTHDC1 HKO]

ABSTRACT: The goal of this study is to investigate how YTHDC1 regulates liver function.

ORGANISM(S): Mus musculus

PROVIDER: GSE227172 | GEO | 2025/06/15

REPOSITORIES: GEO

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The effects of YTHDC1 on liver function [YTHDC1 HKO]

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The effects of YTHDC1 on islet β-cell function

Project description:The goal of this study is to investigate how YTHDC1 regulates islet β-cell function. Our study represents the first detailed analysis of islet transcriptomes from Ythdc1flox/flox and Ythdc1-βKO mice, generated by RNA-seq technology. The RNA-seq analysis showed that 2869 genes were downregulated and 2825 genes were upregulated in the pancreatic islets of Ythdc1-βKO mice.

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Assay for transposase-accessible chromatin-sequencing (ATAC-seq) of liver samples from Ythdc1flox/flox and Ythdc1-HKO mice, respectively.

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The effects of ALKBH5 on liver function [RNA-seq]

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RNA sequencing analyses of human liver cancer cell line HepG2 treated with control shRNA and YTHDC1 knockdown shRNA

Project description:YTHDC1 is one of m6A reader proteins exerting multifaceted effects on determining the fate of m6A RNA within the nucleus.To understand how YTHDC1 contributes to liver cancer progression, we conducted RNA-seq assay in shCtrl and shDC1 HepG2 cells and aimed to identified YTHDC1-responsive genes.

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