Genomics

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Characterization of miR-34 effectors in colorectal cancer cells.


ABSTRACT: MiR-34a and miR-34b/c encoding genes represent direct targets of the p53 tumor suppressor. MiR-34a/b/c mediate tumor suppression by p53 via down-regulation of the expression of specific target mRNAs. Here, we characterized the miR-34 effectors using a CRISPR/Cas9-approach in HCT116 cells with or without 5-FU treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE227230 | GEO | 2023/08/21

REPOSITORIES: GEO

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