Genomics

Dataset Information

0

Systems analysis of the Merck Ad5/HIV vaccine reveals robust induction of a core innate immune gene network: in vivo analysis


ABSTRACT: Here we applied a systems approach to define human innate immune signatures following MRKAd5/HIV immunization and to analyze the effects of pre-existing Ad5 immunity. We defined the global early immune response to MRKAd5/HIV by profiling the PBMC transcriptomes from seven Ad5Neg individuals pre- and post-vaccination in vivo. Since the Step Study results suggested a deleterious effect of pre-existing Ad5 nAb on vaccine immunogenicity, we examined the vaccine-induced transcriptional responses from two Ad5Med and one Ad5Low individual

ORGANISM(S): Homo sapiens

PROVIDER: GSE22768 | GEO | 2012/11/20

SECONDARY ACCESSION(S): PRJNA129109

REPOSITORIES: GEO

Similar Datasets

| E-GEOD-22768 | biostudies-arrayexpress
2012-11-20 | GSE22769 | GEO
| E-GEOD-22769 | biostudies-arrayexpress
| E-GEOD-22822 | biostudies-arrayexpress
2012-11-20 | GSE22822 | GEO
| E-MTAB-11084 | biostudies-arrayexpress
| E-MTAB-11117 | biostudies-arrayexpress
2016-12-31 | GSE89148 | GEO
| 2317938 | ecrin-mdr-crc
| E-GEOD-73118 | biostudies-arrayexpress