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In depth analysis reveals promotion of human macrophage polarization towards a proinflammatory M1 phenotype by TRAIL

ABSTRACT: The study aimed to investigate the impact of TRAIL on primary human M1, M2a and M2c macrophage polarization. Primary human monocyte-derived macrophages were pre-stimulated with TRAIL and then either left unpolarized (M0) or polarized into M1, M2a, or M2c phenotypes Then, RNA sequencing analysis was performed in 4 healthy donors including treated and control groups for one time point to analyze the differentially expressed M1 and M2 markers in TRAIL treated vs control groups.

ORGANISM(S): Homo sapiens

PROVIDER: GSE227737 | GEO | 2023/09/11

REPOSITORIES: GEO

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