Effect of Omomyc on the in vivo growth of melanomas [SkMel147]

ABSTRACT: Skin melanomas are highly aggressive and metastatic. Omomyc is the best MYC inhibitor currently available. We analysed the effect of Omomyc expression in a transgenic and inducible (upon Doxycycline addition) manner in melanoma cells in vivo in two different melanoma cell lines: A375 (mutated in BRAF), SkMel147 (mutated in NRAS). We used microarrays to detail the change in the gene expression programs induced by Omomyc on day 7.

ORGANISM(S): Homo sapiens

PROVIDER: GSE227842 | GEO | 2023/04/09

REPOSITORIES: GEO