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Cell-cell interactome of the hematopoietic niche and its changes in acute myeloid leukemia

ABSTRACT: Acute myeloid leukemia (AML) is an aggressive cancer which causes the rapid proliferation of immature myeloid-lineage blood cells (myeloblasts) in the bone marrow. These leukemic cells receive trophic signals from the bone marrow micro-environment (BMM) in which they reside, that are essential to the initiation and maintenance of the disease. Because this is a complex and heterogeneous tissue, many aspects of this environment remain poorly characterised due to experimental hurdles. Here we performed single-cell RNA-sequencing of bone marrow aspirates from 10 AML patients across multiple key timepoints in disease progression (diagnosis, post-treatment, relapse).

ORGANISM(S): Homo sapiens

PROVIDER: GSE227903 | GEO | 2023/06/13

REPOSITORIES: GEO

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