Transcriptomics

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Knockdown Gene Expression Profile of potential key drivers for Alzheimer’s Disease in human iPSC-derived neurons.


ABSTRACT: In this study, we construct network models by integrating multi-omics data in ROSMAP and MAYO cohort in AMP-AD consortium and infer 19 potential key drivers for Alzheimer’s Disease and related dementia (ADRD). To validate these 19 targets in modulating AD-related pathology (Amyloid-beta and phosphorylated-Tau) and investigating the biological functions and pathways they regulate, we performed RNAi-based knockdown of 19 targets inferred by computational systems biology model in human iPSC-derived neurons (iNs) and measured gene expression profile for each knockdown by RNAseq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE228156 | GEO | 2023/04/01

REPOSITORIES: GEO

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