Effect of BAF disruption on chromatin accessibility in activated CD8+ T cells [ATAC-seq]

ABSTRACT: To investigate the role of cBAF in regulation of Tbet binding, polyclonal naive CD8 T cells were stimulated for 48h with anti-CD3, CD28, and hIL-2. Cells were then treated with DMSO, ACBI1, or BRM014 for 6 hours, and treated with recombinant mouse IL-12 for the last two hours of inhibitor treatment. Chromatin accessibility profiling was performed via ATAC-seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE228193 | GEO | 2023/06/13

REPOSITORIES: GEO