ALK upregulates POSTN and WNT signaling to drive neuroblastoma

ABSTRACT: The goal of this study is to identify the mechanism for how ALK promotes tumorigenesis in neuroblastoma. We developed a human stem cell model of neuroblastoma and generated isogenic tumors using MYCN and MYCN/ALK. RNAseq analysis of both tumors revealed an enrichment in focal adhesion signaling and allowed us to find POSTN as a key mediator of ALK-mediated tumor growth.

ORGANISM(S): Homo sapiens

PROVIDER: GSE228194 | GEO | 2024/03/21

REPOSITORIES: GEO