Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The transcriptional effects of osteocyte-derived mitochondria on endothelial cells

ABSTRACT: In this study, osteocytes were proved to be capable of delivering mitochondria to endothelial cells in cortical bone and promotes its angiogenesis. By utilizing RNA seq, we investigated the effect of osteocytes-derived mitochondria on endothelial cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE228304 | GEO | 2025/06/18

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Osteocytes regulate transcortical blood vessel network by transferring mitochondria to endothelial cells in cortical bone

Project description:In this study, mitochondria were proved to be capable of delivering mitochondria to endothelial cells of transcortical blood vessel and promotes its angiogenesis. By utilizing RNA seq, we investigated the effect of osteocytes-derived mitochondria on endothelial cells.

2025-02-08 | GSE224786 | GEO

Regulation of blood-brain barrier by astrocyte through mitochondrial transfer II

Project description:In our study, astrocytes were proven to be capable of delivering mitochondria to endothelial cells, and thus regulate the integrity of blood-brain barrier. We utilized RNA seq to investigate the effect of astrocyte-derived mitochondria on endothelial cells.

2024-07-31 | GSE206414 | GEO

Effect of osteocytes mitochondria on chondrocytes

Project description:Effect of osteocytes mitochondria on chondrocytes

| PRJNA909166 | ENA

Effect of osteocytes mitochondria on OA chondrocytes

Project description:Effect of osteocytes mitochondria on OA chondrocytes

| PRJNA907788 | ENA

The transcriptional effects of osteocyte-derived mitochondria on endothelial cells

Project description:The transcriptional effects of osteocyte-derived mitochondria on endothelial cells

| PRJNA949228 | ENA

Osteocytes regulate transcortical blood vessel network by transferring mitochondria to endothelial cells in cortical bone

Project description:Osteocytes regulate transcortical blood vessel network by transferring mitochondria to endothelial cells in cortical bone

| PRJNA932471 | ENA

Small RNA sequencing of mitochondria and whole fraction of human umbilical vein endothelial cells treated with hydrogen peroxide

Project description:Numerous miRNAs have been found in mitochondria and these mitochondrial miRNAs have been shown important roles in many physiological and pathophysiological processes. However, the dynamic changes of miRNA distribution in mitochondria in the endothelial oxidative injury are still unclear. Therefore, miRNAs levels in whole cells and mitochondria of hydrogen peroxide treated endothelial cells for 12h and 18h were analyzed by small RNA sequencing.

2023-10-31 | E-MTAB-9851 | biostudies-arrayexpress

Characterize osteocyte transcriptome under control of PPARa

Project description:RNA-seq analysis of transcriptome of osteocytes isolated from femora cortical bone of 5 mo old C57BL6 mice with WT or PPARa KO genotype. Conclusion: In osteocytes, PPARα controls large number of transcripts coding for signaling proteins and osteocyte secretome which regulates development of bone marrow adipose tissue and peripheral fat metabolism.

2023-03-28 | GSE225595 | GEO

Magnesium promotes vascularized osseointegration in diabetic states

Project description:The poor osseointegration of dental implants in diabetic patients has become a long-standing clinical problem. Magnesium has been proved to promote bone healing under normal conditions. Here, we elucidate the mechanism by which Mg2+ promotes vascularized osseointegration in diabetic status. We generated a diabetic mice model and demonstrated the alveolar bone healing was compromised, with significantly decreased angiogenesis. We then developed Mg-coating implants with hydrothermal synthesis. These implants sucessfully improved the vascularization and osseointegration in diabetic status. Mechanically, Mg2+ promoted the degradation of Kelch-like ECH associated protein 1 (Keap1) and the nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2) by up-regulating the expression of sestrin 2 (SESN2) in endothelial cells, thus reducing the elevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia. Altogether, our data proved that Mg2+ promoted vascularized osseointegration in diabetic mice by regulating endothelial mitochondrial metabolism.

2024-02-07 | GSE236139 | GEO

Osteocyte-derived extracellular vesicles mediate the bone-to-cartilage crosstalk and promote osteoarthritis progression [only osteocyte-enriched subchondral bone]

Project description:Osteoarthritis (OA) is the most common degenerative joint disease. During its initiation and early progression a disruption in subchondral bone (SCB) remodeling, induced by excessive and cumulative mechanical loading, occurs before cartilage degeneration. While it is known that osteocytes in the SCB are mainly responsible for mechanosensing, their role in the early phases of OA are still unclear. Here, we found that mechanical stress induces SCB osteocytes to secrete extracellular vesicles (EVs) that accelerate cartilage metabolic dysregulation. By gain- and loss-of function experiments we show that such EVs via miR-23b-3p promote cartilage catabolism while inhibiting their anabolism. Mechanistically, miR-23b-3p inhibits mitophagy by targeting OTUD4 to promote this metabolic skewing. Further, by inhibiting miR-23b-3p in either osteocytes or chondrocytes we could alleviate cartilage degeneration and OA progression in a mouse model. Together, our findings show that SCB osteocytes communicate with chondrocytes via EVs and that targeting a key EV-derived miRNA can ameliorate OA progression.

2025-04-12 | GSE284357 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data