Ethoxysanguinarine ameliorates vascular remodeling by regulating TGF-β1/Smad2/3 signaling pathway in Hypertension：An in vitro and in vivo approach

ABSTRACT: The goals of this study is to compare the differently expressed genes in abdominal aortaof WKY and SHR with or without Ethoxysanguinarine (ETH) treatment. The SHRs (n=12) were randomly divided into 2 groups: SHR, and SHR +ETH (3.5mg/kg/d) groups (n=6 for each group). WKY rats (n=6) were set as control. Rats in WKY and SHR groups were intragastrically with double distilled water (dd H2O), while rats in SHR + ETH (3.5mg/kg/d) group were intragastrically with 3.5 mg/kg/d of ETH for 10 weeks. Then the vascular vessel tissues were used to identify differentially expressed genes among different groups.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE228356 | GEO | 2024/03/27

REPOSITORIES: GEO