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SARS-CoV-2 proteins inhibit mitochondrial HIGD1A to induce complement-mediated endothelial cell injury

ABSTRACT: Purpose: The purpose is to systemically identify the genes regulating CD59 expressed on endothelial cells by Crispr/cas9-gRNA library screening Methods: We profiled gRNA sequnecing of endothelial cells with significant CD59 changes and those cells without significant CD59 changes Results: several genes with upregulated or downrgulated were identified as regulators of CD59 in endothelial cells with the edited genome

ORGANISM(S): Homo sapiens

PROVIDER: GSE228503 | GEO | 2025/03/12

REPOSITORIES: GEO

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Urine complement analysis implies complement activation is involved in membranous nephropathy

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