Gene expression profile at single cell level of virus-specific CD8+ T cells in subjects with past or current HCV infection.

ABSTRACT: CD8+ T cells play a central role in antiviral control. We used single cell RNA sequencing (scRNA-seq) to analyze the differences of HCV-specific CD8+ T cells isolated from subjects that are chronically infected by HCV, individuals that spontaneously resolved an acute HCV infection, and chronic HCV patients in treatment with direct-acting antiviral (DAA). We also profiled non-HCV virus-specific cells (CMV and FLU) to analyze the impact of HCV infection on the adaptive immune response.

ORGANISM(S): Homo sapiens

PROVIDER: GSE228763 | GEO | 2023/06/08

REPOSITORIES: GEO