Down regulation of Monocyte miRNAs: Implications for Immune Dysfunction and Disease Severity in Drug-Resistant Tuberculosis

ABSTRACT: Monocyte miRNAs govern both protective and pathological responses during tuberculosis through their differential expression and emerged as potent target for biomarker discovery and host-directed therapeutics. Thus, our profound interest is to look at the miRNA profile of sorted monocytes across TB disease spectrum (drug-resistance TB (DR-TB), drug-sensitive TB (DS-TB) and latent TB) and healthy individuals (HC) to understand the underlying pathophysiology and their regulatory mechanism.

ORGANISM(S): Homo sapiens

PROVIDER: GSE229020 | GEO | 2023/07/19

REPOSITORIES: GEO