Project description:Using a mouse model of lupus skin disease, we find that skin-infiltrating CD4+ and CD8+ T cells express high levels of HIF-1, demonstrate a strong cytotoxic signature, and the cytotoxic signature decreases after pharmacologic HIF1 inhibition.
Project description:Using a mouse model of lupus skin disease, we find that skin-infiltrating CD4+ and CD8+ T cells express high levels of HIF-1 and demonstrate a strong cytotoxic signature.