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Effect of PI3Kgamma inhibition on inflammation in a mouse model of COVID-19

ABSTRACT: SARS-CoV-2 infections induce aberrant pulmonary and systemic inflammation, vascular leak, coagulation and fatal organ damage. To identify therapeutic strategies to suppress COVID-19-associated inflammation, we sequenced lung tissue from sham infected mice and mice infected with SARS-CoV-2 that were treated with the cancer therapeutic IPI-549 (eganelisib) or vehicle. IPI-549 suppressed signatuers of pulmonary inflammation and reduced signatures of lung damage. These studies demonstrate the essential role of myeloid cells and PI3Kγ in SARS-CoV-2 inflammatory disease and support the use of myeloid cell inhibitors such as IPI-549 to suppress inflammation and promote survival in pulmonary infections like SARS-CoV-2.

ORGANISM(S): Mus musculus

PROVIDER: GSE229570 | GEO | 2023/04/30

REPOSITORIES: GEO

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PI3Kg inhibition circumvents inflammation and mortality in SARS-CoV-2 and other infections

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