Project description:To determine the circRNA expression profile in early stage lung adenocarcinoma and matched non-tumor tissues, we used circRNA microArray analysis form Arraystar to examine the expression of circRNAs Lung adenocarcinoma, a form of NSCLC with high lethality at advanced stage, is becoming more popular in women, non- or never-smokers, and even young adult. However, there are no effective early diagnosis methods at present for patients to cure timely. Circular RNAs (circRNAs) as a special novel, stable, and conserved non-coding RNA in mammalian cells have been reported to be widely involved in the processes of cancer disease. Yet, it is still a puzzle which specific circRNAs are involved in the development of early stage lung adenocarcinoma. Here, tumour samples and paired adjacent normal tissues from 4 patients with early stage lung adenocarcinoma were selected for investigating the expression profile of circRNAs by using the high-throughput circRNA microarray. Bioinformatic analyses were conducted to screen those differentially expressed circRNAs. This work illustrates that clusters of circRNAs are aberrantly expressed in early stage lung adenocarcinoma, which might be able to provide potential targets for the early diagnosis of this disease and new genetic insights into lung cancer.

2019-06-26 | GSE101684 | GEO

Stable and discriminating radiomic predictor of recurrence in early stage non-small cell lung cancer: Multi-site study.

Project description: Not available

| S-EPMC7141152 | biostudies-literature

A prognostic predictor panel with DNA methylation biomarkers for early-stage lung adenocarcinoma in Asian and Caucasian populations.

Project description: Not available

| S-EPMC4969679 | biostudies-other

Microarray analysis of the expression profile of immune-related gene in rapid recurrence early-stage lung adenocarcinoma.

Project description: Not available

| S-EPMC7382661 | biostudies-literature

Inflammation in the tumor-adjacent lung as a predictor of clinical outcome in lung adenocarcinoma

Project description:This SuperSeries is composed of the SubSeries listed below.