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Customized PanCancer Immune panel on heart allografts subjected to 8hrs cold ischemic storage in mice cardiac heart transpalnatation model.

ABSTRACT: We tested the impact of prolonged graft cold storage on graft injury.Transcroptome analysis using total RNA isolated from the allografts showed differential expression of transcripts in this model.

ORGANISM(S): Mus musculus

PROVIDER: GSE229880 | GEO | 2024/03/20

REPOSITORIES: GEO

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PanCancer Immune panel on infiltrating memory CD8 T cells purified from the allografts subjected to prolonged cold ischemic storage in mice cardiac heart transpalnatation model.

Project description:We testd differences in hetelogous memory CD8 T cells and donor specific memory CD8 T cells infiltrating A/J heart allografts from of CTLA-4Ig non- or conditioned B6 recipients.Transcroptome analysis using memory CD8 T cell lysates isolated from the allografts showed differential expression of transcripts in this model.

2024-03-20 | GSE233620 | GEO

PanCancer Immune panel on heart allografts in an antibody mediated Chronic Vasculopathy mouse model

Project description:We have developed a novel antibody-mediated CAV model using CCR5 CD8 double knock out mice.Transcroptome analysis using total RNA isolated from the allografts in this recipients showed differential expression of transcripts in this model.

2022-04-12 | GSE200623 | GEO

PanCancer Immune panel on heart allografts in an antibody mediated Chronic Vasculopathy mouse model

Project description:PanCancer Immune panel on heart allografts in an antibody mediated Chronic Vasculopathy mouse model

| PRJNA825552 | ENA

Identification of microRNAs involved in acute rejection and spontaneous tolerance in murine hepatic allografts

Project description:Graft acceptance without the need for immunosuppressive drugs is the ultimate goal of transplantation therapy. In murine liver transplantation, allografts are accepted across major histocompatibility antigen complex barriers without the use of immunosuppressive drugs and constitute a suitable model for research on immunological rejection and tolerance. MicroRNA (miRNA) has been known to be involved in the immunological responses. In order to identify mRNAs in spontaneous liver allograft tolerance, miRNA expression in hepatic allografts was examined using this transplantation model. According to the graft pathological score and function, miR-146a, 15b, 223, 23a, 27a, 34a and 451 were upregulated compared with the expression observed in the syngeneic grafts. In contrast, miR-101a, 101b and 148a were downregulated. Our results demonstrated the alteration of miRNAs in the allografts and may indicate the role of miRNAs in the induction of tolerance after transplantation. Furthermore, our data suggest that monitoring the graft expression of novel miRNAs may allow clinicians to differentiate between rejection and tolerance. A better understanding of the tolerance inducing mechanism observed in murine hepatic allografts may provide a therapeutic strategy for attenuating allograft rejection.

2014-10-21 | GSE52164 | GEO

Identification of microRNAs involved in acute rejection and spontaneous tolerance in murine hepatic allografts

2014-10-21 | E-GEOD-52164 | biostudies-arrayexpress

Molecular changes in kidney allografts after simultaneous liver-kidney compared with solitary kidney transplantation

Project description:The aim of this study was to investigate correlations between early subclinical findings (10 and 90 day histology and gene expression data) and late outcomes (transplant glomerulopathy and graft loss) in positive crossmatch kidney transplants (+XMKTx). Our goal was threefold: first, to confirm that intragraft molecular changes at 12m post-transplant are associated with the observed histologic changes in SLK transplant recipients, compared with KTA transplant recipients; second, to ascertain whether specific molecular pathways/markers that are not accounted for by routine histology are differentially expressed in the kidney allografts of the SLK transplant recipients; and third, to determine whether a molecular signature that is uniquely associated with simultaneous liver transplantation can be identified in kidney allografts.

2017-04-14 | GSE97780 | GEO

Molecular changes in kidney allografts after simultaneous liver-kidney compared with solitary kidney transplantation

2017-04-14 | E-GEOD-97780 | biostudies-arrayexpress

MOLECULAR CHARACTERIZATION OF LIVER ALLOGRAFTS FROM OPERATIONALLY TOLERANT TRANSPLANT RECIPIENTS

Project description:This SuperSeries is composed of the following subset Series: GSE26622: MOLECULAR CHARACTERIZATION OF LIVER ALLOGRAFTS FROM OPERATIONALLY TOLERANT TRANSPLANT RECIPIENTS (Affymetrix) GSE26625: MOLECULAR CHARACTERIZATION OF LIVER ALLOGRAFTS FROM OPERATIONALLY TOLERANT TRANSPLANT RECIPIENTS (Illumina) Refer to individual Series

2012-01-09 | E-GEOD-26627 | biostudies-arrayexpress

RNA-sequencing of Rabbit Hamstring Allografts

Project description:RNA-sequencing of Rabbit Hamstring Allografts

| PRJNA515919 | ENA

Gene expression data from endothelial cells and leukocytes enriched from transplanted rat hearts

Project description:Transcriptome analyses of organ transplants have until now usually focused on whole tissue samples containing activation profiles from different cell populations. Here, we enriched endothelial cells from rat cardiac allografts and isografts, establishing their activation profile at baseline and on day 2, 3 and 4 after transplantation. Modulated transcripts were assigned to three categories based on their regulation profile in allografts and isografts. Categories A and B contained the majority of transcripts and showed similar regulation in both graft types, appearing to represent responses to surgical trauma. By contrast, category C contained transcripts that were partly allograft-specific and to a large extent associated with interferon-ï§-responsiveness. Several transcripts were verified by immunohistochemical analysis of graft lesions, among them the matricellular protein periostin which was one of the most highly upregulated transcripts but has not been associated with transplantation previously. In conclusion, the majority of the differentially expressed genes in graft endothelial cells are affected by the transplantation procedure whereas relatively few are associated with allograft rejection. Endothelial cells were enriched from control/non-transplanted hearts and from allografts (DA to Lewis) and isografts (Lewis to Lewis) harvested at day 2, 3 and 4 after transplantation. Three biological replicates from each time point and graft type were analyzed (a total of 24 arrays). Leukocytes were enriched from allografts at day 2 (n=1), day 3 (n=2) and day 4 (n=1) after transplantation.

2010-07-29 | E-GEOD-16695 | biostudies-arrayexpress

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