Distinct transcriptional profile in CD4+ T-lymphocytes among obese children with asthma

ABSTRACT: Obesity is a risk factor for asthma severity and morbidity, displaying a distinct clinical phenotype that is less responsive to inhaled corticosteroids. CD4+ T-cells are central to the immunologic pathways of asthma and may contribute to the unique obese asthma phenotype. We sought to characterize the single cell CD4+ transcriptional profile among obese children with asthma compared to matched normal weight children with asthma.

ORGANISM(S): Homo sapiens

PROVIDER: GSE230024 | GEO | 2025/05/01

REPOSITORIES: GEO