Transcriptomics

Dataset Information

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BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides


ABSTRACT: BACE1 role in reactive astrocytes are unknown. We used single cell RNA sequencing (scRNA-seq) to analyze reactive astrocytes in mice with and without germline Bace1. We also examine reactive astrocytes in the case of adult Bace1 conditional knockout on a 5xFAD Alzheimer's disease mouse model.

ORGANISM(S): Mus musculus

PROVIDER: GSE230116 | GEO | 2023/04/24

REPOSITORIES: GEO

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