DGCR8 promotes intestinal regeneration of damaged epithelium in a p53 signaling dependent manner

ABSTRACT: TO explore role of DGCR8, a essential factor in canonical microRNAs biogenesis, in intestinal epithelial regeneration, we performed gene expression profiling analysis using data obtained from RNA-seq of intestinal organoids, intesitnal stem cells, and crypts from mice following 5-FU administration. To further investigate which microRNA was responsible for intestinal regeneration, we also performed small RNA sequencing with intestinal stem cells and intestinal epithelia cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE230172 | GEO | 2023/12/13

REPOSITORIES: GEO