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Comparison of global gene expression profile associated with inhalation anesthesia between sevoflurane and desflurane

ABSTRACT: Comparative gene expression profiling analysis of RNA-seq data for livers from rats subjected to inhalational anesthesia with either sevoflurane or desflurane and their controls that were treated with sevoflurane or desflurane only briefly until the loss of their consciousness.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE230365 | GEO | 2023/10/03

REPOSITORIES: GEO

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Project description:Although sevoflurane is one of the most commonly used inhalational anesthetic agent, the popularity of desflurane is increasing to a similar level. The main beneficial property of desflurane is the relatively fast emergence of the patient from the anesthetic state after halting its supply compared with anesthesia using other anesthetic agents. However, there has been no comprehensive comparison of the effects of these two anesthetic agents on alterations in liver gene expression profiles in animals, including humans, to assess the kinds of biological abnormalities/changes and their levels in the host. Thus, we compared alterations in the global gene expression profiles in the livers of rats subjected to inhalational anesthesia by sevoflurane or desflurane by a next-generation sequencing method.

2024-02-21 | GSE244436 | GEO

Expression data from sevoflurane anesthesia treated rat

Project description:Long noncoding RNAs (lncRNAs) play important roles in brain function modulation and neurodegenerative diseases. However, whether lncRNA regulations are involved in the mechanisms of perioperative neurocognitive disorders (PNCD), especially in anesthesia related brain dysfunction, remains unknown. We explored the expression and regulation pattern profiles of lncRNAs in the hippocampus of aged rats after sevoflurane anesthesia with microarrays.

2020-12-29 | GSE139220 | GEO

Expression data from sevoflurane anesthesia treated rat

Project description:Expression data from sevoflurane anesthesia treated rat

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sevoflurane exposures on neonatal and adult mice,LC-MSMS

Project description:Sevoflurane is the most commonly used general anesthetic in pediatric surgery, but it has the potential to be neurotoxic. Previous research found that long-term or multiple sevoflurane exposures could cause cognitive deficits in newborn mice but not adult mice, whereas short-term or single inhalations had little effect on cognitive function at both ages. The mechanisms behind these effects, however, are unclear. In the current study, 6- and 60-day-old C57bl mice in the sevoflurane groups were given 3% sevoflurane plus 60% oxygen for three consecutive days, each lasting 2 hours, while those in the control group only got 60% oxygen. The cortex tissues were harvested on the 8th or 62nd day. The tandem mass tags (TMT)pro-based quantitative proteomics combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysi were applied to analyze the influences of multiple sevoflurane anesthesia on the cerebral cortex in mice with various ages. A total of 6247 proteins were measured using the combined quantitative proteomics methods of TMTpro-labeled and LC-MS/MS, 443 of which were associated to the age-dependent neurotoxic mechanism of repeated sevoflurane anesthesia. Our findings would help to further the mechanistic study of age-dependent anesthetic neurotoxicity and contribute to seek for effective protection in the developing brain under general anesthesia.

2022-12-08 | PXD037294 | Pride

Effects of sevoflurane inhalation anesthesia on proliferation and apoptosis of colon cancer cells in vitro: a randomized controlled trial.

Project description:Interventions: Sevo:Sevoflurane inhalation anesthesia was performed during the operation;Pro:propofol intravenous anesthesia was performed during the operation;Sevo+Pro:sevoflurane—propofol combined anesthesia during the operation Primary outcome(s): Postoperative mortality Study Design: Parallel

| 2699849 | ecrin-mdr-crc

Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia

Project description:The purpose of this study is to determine whether anesthesia maintained with propofol results in better one- and five-year-survival than anesthesia maintained with sevoflurane.

| 2154097 | ecrin-mdr-crc

Effects of intravenous anesthesia and inhalation anesthesia on perioperative intestinal immune function and systemic inflammatory response in patients with colon cancer

Project description:Interventions: Group 1 :Morning surgery: intravenous anesthesia;Group 2:Morning surgery: inhalational anesthesia;Group 3:Afternoon surgery: intravenous anesthesia;Group 4:Afternoon surgery: inhalational anesthesia Primary outcome(s): CD+4T cells;Interleukin-22 Study Design: Parallel

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A comparative study of the effects of Remimazolam Tosilate and Sevoflurane on perioperative oxidative stress response in patients undergoing radical surgery for colorectal cancer

Project description:Interventions: The sevoflurane group (S group) :The S group received inhalational anesthesia with sevoflurane for induction and maintenance.;Remazolam group (R group):Induction and maintenance of anesthesia using remidazolam Primary outcome(s): Catalase;Glutathione;Oxidized glutathione;Malondialdehyde;Superoxide dismutase Study Design: Parallel

| 89547 | ecrin-mdr-crc

Propofol and Sevoflurane Anesthesia in Colorectal Cancer Surgery: Incidence of Acute Kidney Injury

Project description:The goal of this observational study is to compare anesthetic modalities (intravenous propofol anesthesia with sevoflurane gas anesthesia) in patients who underwent colorectal cancer resection surgery regarding the outcome of acute kidney injury. The main questions it aims to answer are: * is there a difference in acute kidney injury incidence in the two anesthetic modalities? * is there a difference in plasma creatinine between the two anesthetic modalities? * are there any patient characteristics or intraoperative factors that effect the incidence of acute kidney injury in either anesthetic modality? The study will analyze data from the CAN clinical trial database. (Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia, NCT01975064)

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Gene expression of brain regions activated by sevoflurane and propofol

Project description:The basic mechanisms of action for general anesthesia are not fully understood. We thought differences in the neural activation sites of different types of anesthetics and differences in gene expression changes in those brain regions may lead to differences in the incidence of side effects. We performed gene expression analysis using microarrays in the identified regions that have been related to the mechanisms of anesthetic action and side effects. Gene expression changes in these brain regions were determined for sevoflurane and propofol to understand the mechanisms that cause differences among anesthetics.

2021-12-22 | GSE192399 | GEO

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