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Molecular signatures of CD45+ cells from brain and spleen after intracerebral hemorrhage

ABSTRACT: Leukocyte infiltration accelerates brain injury following intracerebral hemorrhage (ICH). But the involvement of T lymphocytes in this process has not been fully elucidated.To further depict the landscape of the composition and functional states of brain-infiltrating immune cells following ICH, single-cell RNA sequencing was performed to compare the molecular characteristics of CD45+ cells from brain and spleen tissues in ICH and control mice.Our results revealed that brain-infiltrating T cells exhibited enhanced pro-inflammatory and pro-apoptotic signatures.

ORGANISM(S): Mus musculus

PROVIDER: GSE230414 | GEO | 2023/06/07

REPOSITORIES: GEO

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