Metformin restrains ZIKV replication and alleviates virus-induced inflammatory responses in microglia

ABSTRACT: C20 were pre-treated with metformin at specified concentration (5 mM) for 2 h, followed by ZIKV infection at MOI 3. After infection of 1.5 h, cells were washed three times with PBS. Medium containing metformin was again supplemented and maintained during the culture. The total RNA of samples at 16 and 48 h were extracted for RNA-seq analysis. We then performed differential expression analysis using data obtained by RNA-seq of ZIKV infection and metformin treatment (16 h and 48 h).

ORGANISM(S): Homo sapiens

PROVIDER: GSE231200 | GEO | 2023/05/03

REPOSITORIES: GEO