Chronic hypercapnia-induced gene expression profiles in the brain

ABSTRACT: To test the hypothesis that increasing severity of chronic hypercapnia elicits distint gene expression profiles in important brainstem regions of cardiorespiratory control, three groups of goats (female; n=6/group) were exposed either 14 days of room air (RA), 14 days of 6% inspired CO2 (mild CH), or 7d of 6% InCO2 followed by 7d of 8% InCO2 (moderate CH). Following 14 days of exposure 4 target sites were collected (3 brainstem/1 cortical) for gene expression profiling analysis using bulk-tissue RNA-sequencing. Comparisons were made across all target sites comparing room air animals to either mild or moderate CH.

ORGANISM(S): Capra hircus

PROVIDER: GSE231308 | GEO | 2023/05/01

REPOSITORIES: GEO