Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells

ABSTRACT: This study shows in a polyclonal setting that routine exposure to food protein promotes accumulation of antigen-experienced CD4+ T cells in the intestinal epithelium, which acquire a cytotoxic tissue-resident transcriptional program. This process is disrupted upon either allergic sensitization or tolerance.

ORGANISM(S): Mus musculus

PROVIDER: GSE231351 | GEO | 2023/05/13

REPOSITORIES: GEO