Gene expression in self-activating CAR-T cells with CD28 or 4-1BB costimulatory domains.

ABSTRACT: We observed self-activation of SKM-CAR-T cells which target novel mesothelioma antigen. CAR-T with CD28 costimulatory domain showed signs of exhaustion while those with 4-1BB costimulatory domain did not. Changes in the gene expression by substituting CD28 co-stimulatory domain to 4-1BB co-stimulatory domain was investigated.

ORGANISM(S): Homo sapiens

PROVIDER: GSE231443 | GEO | 2023/05/28

REPOSITORIES: GEO